For me, I will suggest you to clean the TBU at least once in a fortnight. If you are a heavy user, and every day you need to backup at last 400GB of data, then you might need to consider clean it at least once in a week.
Few weeks ago, I noticed even some of the IT personnel did schedule the drive cleaning, but they didn't know how many times that a cleaning tape can be used, and they just keep cleaning the drive with a cleaning media which already exceed its life span.
Please take a look from the below description:
An LTO cleaning cartridge can be used approximately 50 times, and the inventory count shows 50 cleans remaining until you load the tape into a drive for the first time. An SDLT-320 cleaning cartridge can be used approximately 20 times
For more information, you may refers to below URL:
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